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| Status |
Public on May 19, 2021 |
| Title |
Distal regulation mediated Core Transcriptional Regulatory Circuitry in Esophageal Squamous Cell Carcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
In esophageal squamous cell carcinoma (ESCC), the core regulatory circuitry is ill-defined and the limited clinical approaches are available currently for the treatment of ESCC. Here, using enhancer profiling and CRC programme, we generated ESCC-dependent epigenomic-transcriptional regulatory circuitry, elaborated the exquisite work model mediated by core TFs and SEs through physical interaction between enhancers and promoter, and identified the crucial target of ESCC regulatory network.
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| Overall design |
By integration of enhancer profiling and chromatin accessibility, we establish super-enhancer (SE) mediated core regulatory circuitry (CRC) for esophageal squamous cell carcinoma (ESCC) and identify tumor cells-dependent SE-associated TFs-TP63, SOX2 and KLF5.
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| |
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| Contributor(s) |
Jiang Y, Jiang Y, Li C, Ying Z, Dakle P, MJ F, Lin D, Koeffler HP |
| Citation(s) |
32619460 |
| |
| Submission date |
Apr 20, 2020 |
| Last update date |
May 19, 2021 |
| Contact name |
Pushkar Dakle |
| Organization name |
Cancer Science Institute of Singapore
|
| Street address |
14 Medical Dr
|
| City |
Singapore |
| ZIP/Postal code |
117599 |
| Country |
Singapore |
| |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA626545 |
| SRA |
SRP257490 |
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