|
| Status |
Public on Jan 10, 2021 |
| Title |
PTBP1 is necessary for dendritic cells to regulate T cells homeostasis and antitumor immunity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Dendritic cells (DCs) play an important role in innate and adaptive immunity. DCs could sense environment pathogens and tumors, presenting those antigens to T cells. PTBP1, an RNA-binding protein, the function in DCs is unknown. Here, we found PTBP1 specific deficiency in DCs could impair T cell homeostasis. PTBP1 deletion in DCs could enhance antitumor immunity and increase asthma exacerbation. Further studies demonstrate that PTBP1 negatively regulates the induction of a subset of IFN-response genes. These findings revealed the novel functions of PTBP1 in DCs and might be a potential therapeutic target for tumors.
|
| |
|
| Overall design |
Here, we performed RNA-seq of Dendritic cells(DCs) from Ptbp1 deficient mouses and WT to further study the molecular changed between KO and WT.
|
| |
|
| Contributor(s) |
Xu C, Geng G, Zhu Y, Shi L |
| Citation(s) |
33421118 |
| |
| Submission date |
Jun 27, 2020 |
| Last update date |
Jan 10, 2021 |
| Contact name |
Changlu Xu |
| E-mail(s) |
[email protected]
|
| Organization name |
Chinese Academy of Medical Sciences & Peking Union Medical College
|
| Department |
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital
|
| Street address |
288 Nanjing Rd, Heping
|
| City |
TianJin |
| State/province |
TianJin |
| ZIP/Postal code |
300020 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (10)
|
|
| Relations |
| BioProject |
PRJNA642299 |
| SRA |
SRP269015 |
Less...
More...