|
| Status |
Public on May 17, 2021 |
| Title |
The microRNA landscape of MYCN-amplified neuroblastoma |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
Neuroblastoma is a common childhood cancer with almost a third of those affected still dying, thus new therapeutic strategies need to be explored. Current experimental therapies focus mostly on inhibiting oncogenic transcription factor signalling. Dysregulation of miRNAs has oncogenic or suppressive tumor functions in a variety of cancer, also including neuroblastoma. Therefore, we investigated the miRNA landscape in 97 neuroblastoma samples from different INSS stages, including MYCN-amplified (MNA) tumor samples.
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| |
|
| Overall design |
Small RNA-sequencing (miRNA) of neuroblastoma samples.
|
| |
|
| Contributor(s) |
Misiak D, Hagemann S, Bell JL, Busch B, Lederer MI, Bley N, Schulte JH, Hüttelmaier S |
| Citation(s) |
34026620 |
| |
| Submission date |
Aug 09, 2020 |
| Last update date |
May 30, 2021 |
| Contact name |
Danny Misiak |
| E-mail(s) |
[email protected]
|
| Phone |
+49345573962
|
| Organization name |
Martin Luther University Halle-Wittenberg
|
| Department |
Molecular Cell Biology
|
| Lab |
Hüttelmaier Lab
|
| Street address |
Kurt-Mothes-Str. 3a
|
| City |
Halle (Saale) |
| ZIP/Postal code |
06120 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL15456 |
Illumina HiScanSQ (Homo sapiens) |
|
| Samples (97)
|
|
| Relations |
| BioProject |
PRJNA656107 |
| SRA |
SRP276981 |
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