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Series GSE160294 Query DataSets for GSE160294
Status Public on Nov 08, 2021
Title Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Vaccination induced CD4 T cells prevent B cell decimation by turning on a germinal center like transcriptional program. This cellular differentiation is similiar to the one observed when type I interferon receptor-deficient (IFNAR-/-) instead of wt mice are used as recipients.
 
Overall design Analysis of KL25HL B cells recovered from LCMV-infected wt mice with either one of two forms of pre-existing CD4 T help (LM61 pre-immunization or SM CD4 T cell adoptive transfer) or no pre-existing T help wt mice (LM immunization) or KL25HL B cells recovered from IFNAR-/- mice without pre-existing CD4 T help.
 
Contributor(s) Narr K, Geier F, Pinschewer DD
Citation(s) 34772811
Submission date Oct 28, 2020
Last update date Nov 18, 2021
Contact name DBM Bioinformatics Core Facility
Phone +41612073541
Organization name University of Basel
Department Departement of Biomedicine
Street address Hebelstrasse 20
City Basel
State/province BS
ZIP/Postal code 4053
Country Switzerland
 
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (16)
GSM4870851 LM.gp61.1
GSM4870852 LM.gp61.2
GSM4870853 LM.gp61.3
Relations
BioProject PRJNA672903
SRA SRP289455

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE160294_counts.tsv.gz 825.4 Kb (ftp)(http) TSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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