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| Status |
Public on Nov 17, 2020 |
| Title |
NOP10 predicts NSCLC prognosis and its associated small nucleolar RNAs drive proliferation and migration [ncRNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
Non-coding RNAs are critical players in non-small cell lung cancer (NSCLC). In the present study, we investigate the role of H/ACA box snoRNA and snoRNA-bound ribonucleoproteins (RNP) in the tumorigenesis of NSCLC.
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| |
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| Overall design |
We used small RNA-Seq to determine the expression profile of small nucleolar RNA (snoRNA) in 7 matched tumor and normal samples from paraffin-embedded tissue from non-small cell lung cancer (NSCLC) patients. To further investigate the role of NOP10, we analyzed A549 cell line with CRISPR Cas9 knock out of NOP10.
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| |
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| Contributor(s) |
Rohde C, Müller-Tidow C, Köhn M |
| Citation(s) |
33288886 |
| |
| Submission date |
Nov 05, 2020 |
| Last update date |
Feb 16, 2021 |
| Contact name |
Christian Rohde |
| E-mail(s) |
[email protected]
|
| Organization name |
Heidelberg University
|
| Lab |
Molecular Hematology and Oncology
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| Street address |
Im Neuenheimer Feld 410
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| City |
Heidelberg |
| ZIP/Postal code |
69120 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL15456 |
Illumina HiScanSQ (Homo sapiens) |
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| Samples (20)
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| This SubSeries is part of SuperSeries: |
| GSE161232 |
NOP10 predicts NSCLC prognosis and its associated small nucleolar RNAs drive proliferation and migration |
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| Relations |
| BioProject |
PRJNA674856 |
| SRA |
SRP291322 |
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