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| Status |
Public on Jan 07, 2010 |
| Title |
Activation of Host Wound Responses in Breast Cancer Microenvironment |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Cancer progression is mediated by processes that are also important in wound repair. As a result, cancers have been conceptualized as overhealing wounds or "wounds that do not heal," and gene expression signatures reflective of wound repair have shown value as predictors of breast cancer survival. Despite the widespread acknowledgment of commonalities between host responses to wounds and host responses to cancer, the gene expression responses of normal tissue adjacent to cancers have not been well characterized.
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| Overall design |
Using RNA extracted from histologically normal breast tissue from 105 patients, 121 arrays were performed, including 72 arrays representing 58 reduction mammoplasty patients and 49 arrays representing 47 cancer patients, we measured whole genome expression profiles and identified a gene expression signature that is induced in response to breast cancer.
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| |
|
| Contributor(s) |
Troester MA |
| Citation(s) |
19887484, 22002519 |
| |
| Submission date |
May 14, 2009 |
| Last update date |
Feb 22, 2018 |
| Contact name |
Melissa Troester |
| E-mail(s) |
[email protected]
|
| Organization name |
University of North Carolina at Chapel Hill
|
| Department |
Epidemiology
|
| Street address |
135 Dauer Drive, CB 7435
|
| City |
Chapel Hill |
| State/province |
NC |
| ZIP/Postal code |
27599 |
| Country |
USA |
| |
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| Platforms (5)
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| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
| GPL8264 |
UNC PerouLab 244K Custom Human Array version 3 |
| GPL8265 |
UNC PerouLab 244K Custom Human Array version 4 |
| GPL8269 |
UNC PerouLab 244K Custom Human Array version 5 |
| GPL8274 |
UNC PerouLab 244K Custom Human Array version 3 with barcode-15847 |
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| Samples (121)
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| Relations |
| BioProject |
PRJNA117229 |
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