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| Status |
Public on Jun 15, 2021 |
| Title |
Transcriptome of differentiated AST and NAS iPS cell lines to human-like dopamine neurons |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
AST- and NAS-derived dopamine neurons were compared for their gene expression profiles after differentiation. Functional data was also collected in terms of neurophysiology.
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| Overall design |
AST- and NAS-derived dopamine neurons were compared for their gene expression profiles after differentiation. Functional data was also collected in terms of neurophysiology. iPSCs were generated from a member of the Iowa kindred carrying a triplication of the SNCA locus (AST) and an unaffected member of the family without this mutation (NAS). Dopamine neurons were differentiated from iPSCs. Transcriptome profiling was done on n=3 AST and n=3 NAS (replicate and independent cell cultures).
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| Contributor(s) |
Khoshbouei H, Martyniuk C, Min L |
| Citation(s) |
34099060 |
| |
| Submission date |
Dec 16, 2020 |
| Last update date |
Nov 13, 2022 |
| Contact name |
Christopher Martyniuk |
| E-mail(s) |
[email protected]
|
| Phone |
3523173905
|
| Organization name |
University of Florida
|
| Street address |
8891 SW 79th Avenue
|
| City |
Gainesville |
| State/province |
FL |
| ZIP/Postal code |
32608 |
| Country |
USA |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA685780 |
| SRA |
SRP298164 |
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