|
| Status |
Public on Feb 19, 2023 |
| Title |
Dynamic expression of smRNA from fecal exosome in disease progression of an inflammatory bowel disorder mouse model |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract affecting over 3 million adults in the United States. Despite being widespread, reliable early diagnostic tests are not available. In order to remedy this, we examined exosomal small RNA (smRNA), specifically targeting microRNA (miRNA) and piRNA from the stool samples of IBD model mice, interleukin 10 knockout mice (IL-10 KO), as a potential diagnostic marker. Stool samples were specifically chosen because they are readily available and collection is noninvasive.
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| Overall design |
Total 17 samples were analyzed; 7 and 10 replicates each for end-point and start-point samples, respectively.
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| |
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| Contributor(s) |
Manning S, Torii S, Atkins HM, Kawasawa YI |
| Citation(s) |
37483339 |
| |
| Submission date |
Feb 22, 2021 |
| Last update date |
Sep 12, 2023 |
| Contact name |
Yuka Imamura Kawasawa |
| E-mail(s) |
[email protected]
|
| Organization name |
Penn State University
|
| Department |
College of Medicine, Pharmacology
|
| Street address |
500 University Dr.
|
| City |
Hershey |
| State/province |
PA |
| ZIP/Postal code |
17033 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (17)
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| Relations |
| BioProject |
PRJNA703978 |
| SRA |
SRP307525 |
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