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| Status |
Public on Dec 09, 2022 |
| Title |
The Keap1-Nrf2-Bach1 signaling mediates UBR7 negative regulation of HK2 to inhibit glycolysis and HCC tumorigenesis |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We found that Keap1-Nrf2 signaling pathway mediates UBR7 to regulate HK2 expression through the modification of histone H2BK120 monoubiquitination, thereby inhibiting glycolysis and HCC tumorigenesis.
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| Overall design |
The promoter regions of genes that bind to H2BK120ub in wild-type and Alb; Cre-UBR7fl/fl mouse liver primary cells were detected by ChiP-seq.
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| Contributor(s) |
Tang B, Zhao L, Li Y, Dai H |
| Citation(s) |
36419136 |
| |
| Submission date |
Apr 27, 2021 |
| Last update date |
Dec 10, 2022 |
| Contact name |
Bo Tang |
| E-mail(s) |
[email protected]
|
| Organization name |
Guangxi Medical University
|
| Street address |
6 Shuangyong Road
|
| City |
Guangxi |
| ZIP/Postal code |
530021 |
| Country |
China |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA725561 |
| SRA |
SRP316621 |
