|
| Status |
Public on May 09, 2011 |
| Title |
Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish |
| Organism |
Danio rerio |
| Experiment type |
Expression profiling by array
|
| Summary |
cdipt is an essential gene in the synthesis of phosphatidylinositol (PtdIns) in the zebrafish, Danio rerio. The zebrafish mutant cdipt^hi559Tg (ZL782) carries a retroviral insertion which inactivates cdipt. Homozygous mutants exhibit hepatocellular endoplasmic reticulum (ER) stress and non-alcoholic fatty liver disease (NAFLD) pathologies at 5 days post fertilization (dpf). This study reveals a novel link between PtdIns, ER stress, and steatosis.
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| |
|
| Overall design |
We compared whole animal gene expression profiles of hi559 mutant larvae with phenotypically wild type larvae from a heterozygote incross in triplicate.
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| |
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| Contributor(s) |
Thakur P, Stuckenholz C, Bahary N |
| Citation(s) |
21488074, 24135483 |
| |
| Submission date |
Aug 18, 2009 |
| Last update date |
Jan 25, 2018 |
| Contact name |
Carsten Stuckenholz |
| E-mail(s) |
[email protected]
|
| Phone |
(412) 648-3159
|
| Fax |
(412) 383-5918
|
| Organization name |
University of Pittsburgh
|
| Department |
Department of Medicine, Division of Hematology and Oncology
|
| Lab |
Bahary
|
| Street address |
3501 Fifth Avenue, Room 5065.5B
|
| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15260 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1319 |
[Zebrafish] Affymetrix Zebrafish Genome Array |
|
| Samples (6)
|
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| Relations |
| BioProject |
PRJNA118453 |
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