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| Status |
Public on Oct 05, 2023 |
| Title |
Expression data that were specifically regulated by lncRNA-HELF (ENSMUST00000147617 ) in livers of mice undergoing CCl4-induced liver fibrosis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Long non-coding RNAs (lncRNAs) are involved in numerous biological functions and pathological processes. In this study, we have identified a novel lncRNA ENSMUST00000147617, named Highly Expressed in Liver Fibrosis (lnc-HELF), which is remarkably up-regulated in mouse and human fibrotic livers. To identify the roles of lnc-HELF in liver fibrosis, we performed RNA-seq to analyze the effect of lnc-HELF deficient on CCl4-induced liver fibrosis. The mice were divided in three groups: mice treated with CCl4 in combination with injection of AAV8-NC (NC_CCl4, n=3), mice treated with CCl4 in combination with injection of AAV8-shRNA-lncHELF1# (sh1_CCl4, n=3) and mice treated with CCl4 in combination with injection of AAV8-shRNA-lncHELF2# (sh2_CCl4, n=3).
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| Overall design |
The mice were divided in three groups: mice treated with CCl4 in combination with injection of AAV8-NC (NC_CCl4, n=3), mice treated with CCl4 in combination with injection of AAV8-shRNA-lncHELF1# (sh1_CCl4, n=3) and mice treated with CCl4 in combination with injection of AAV8-shRNA-lncHELF2# (sh2_CCl4, n=3).
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/37805473/
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| Contributor(s) |
Hong W, Han T, Zhang K |
| Citation(s) |
37805473 |
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| Submission date |
Aug 19, 2021 |
| Last update date |
Jan 06, 2024 |
| Contact name |
Kun Zhang |
| E-mail(s) |
[email protected]
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| Phone |
022-83336819
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| Organization name |
Tianjin medical university
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| Department |
Department of Histology and Embryology
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| Street address |
Qixiangtai Road NO.22
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| City |
Tianjin |
| ZIP/Postal code |
300070 |
| Country |
China |
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| Platforms (1) |
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| Samples (9)
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| GSM5530025 |
mice treated with CCl4 in combination with injection of AAV8-NC, biological rep1 |
| GSM5530026 |
mice treated with CCl4 in combination with injection of AAV8-NC, biological rep2 |
| GSM5530027 |
mice treated with CCl4 in combination with injection of AAV8-NC, biological rep3 |
| GSM5530028 |
mice treated with CCl4 in combination with injection of AAV8-shRNA-lncHELF1#, biological rep1 |
| GSM5530029 |
mice treated with CCl4 in combination with injection of AAV8-shRNA-lncHELF1#, biological rep2 |
| GSM5530030 |
mice treated with CCl4 in combination with injection of AAV8-shRNA-lncHELF1#, biological rep3 |
| GSM5530031 |
mice treated with CCl4 in combination with injection of AAV8-shRNA-lncHELF2#, biological rep1 |
| GSM5530032 |
mice treated with CCl4 in combination with injection of AAV8-shRNA-lncHELF2#, biological rep2 |
| GSM5530033 |
mice treated with CCl4 in combination with injection of AAV8-shRNA-lncHELF2#, biological rep3 |
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| Relations |
| BioProject |
PRJNA756368 |
| SRA |
SRP333388 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE182485_gene_expression.xls.gz |
1.9 Mb |
(ftp)(http) |
XLS |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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