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| Status |
Public on Jan 31, 2010 |
| Title |
Striatum of Huntington's disease model mice [Affymetrix data] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Evaluation of transcriptional changes in the striatum may be an effective approach to understanding the natural history of changes in expression contributing to the pathogenesis of Huntington disease (HD). We have performed genome-wide expression profiling of the YAC128 transgenic mouse model of HD at 12 and 24 months of age using two platforms in parallel; Affymetrix and Illumina. We performed gene expression profiling on the same striatal mRNA across both platforms.
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| Overall design |
Transgenic mice expressing human HD huntingtin with 120 CAG repeats (YAC128) and wildtype littermates were used for the described experiments. The mice were group housed in polystyrene cages under a normal light-dark cycle (6 am to 8 pm) in a clean facility and with free access to water and standard rodent chow. All experiments were performed in accordance with the University of British Columbia animal care committee. Striatal tissue was collected from 12 and 24 month old YAC128 mice and wildtype littermates.
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| Contributor(s) |
Pavlidis P, Becanovic K |
| Citation(s) |
20089533 |
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| Submission date |
Oct 14, 2009 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Paul Pavlidis |
| E-mail(s) |
[email protected]
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| Organization name |
University of British Columbia
|
| Department |
Centre for High-Throughput Biology / Psychiatry
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| Street address |
177 Michael Smith Laboratories 2185 East Mall
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| City |
Vancouver |
| State/province |
British Columbia |
| ZIP/Postal code |
V6T 1Z4 |
| Country |
Canada |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (18)
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| GSM461842 |
YAC128 mouse, 12 months of age (S1bis) |
| GSM461843 |
YAC128 mouse, 12 months of age (S2) |
| GSM461844 |
YAC128 mouse, 12 months of age (S3bis) |
| GSM461845 |
YAC128 mouse, 12 months of age (S4) |
| GSM461846 |
WT mouse, 12 months of age (S5) |
| GSM461847 |
WT mouse, 12 months of age (S6) |
| GSM461848 |
WT mouse, 12 months of age (S7) |
| GSM461849 |
WT mouse, 12 months of age (S8) |
| GSM461850 |
WT mouse, 24 months of age (rlcstriat10) |
| GSM461851 |
YAC128 mouse, 24 months of age (rlcstriat9) |
| GSM461852 |
WT mouse, 24 months of age (rlcstriat8) |
| GSM461853 |
YAC128 mouse, 24 months of age (rlcstriat7) |
| GSM461854 |
YAC128 mouse, 24 months of age (rlcstriat6) |
| GSM461855 |
WT mouse, 24 months of age (rlcstriat5) |
| GSM461856 |
YAC128 mouse, 24 months of age (rlcstriat4) |
| GSM461857 |
YAC128 mouse, 24 months of age (rlcstriat3) |
| GSM461858 |
YAC128 mouse, 24 months of age (rlcstriat2) |
| GSM461859 |
WT mouse, 24 months of age (rlcstriat1) |
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| This SubSeries is part of SuperSeries: |
| GSE19677 |
Striatum of Huntington's disease model mice |
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| Relations |
| BioProject |
PRJNA123785 |
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