|
| Status |
Public on Dec 21, 2021 |
| Title |
Combinatorial Immunotherapy Induces Tumor Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties III |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
This study reveals supeior efficiacy of triple combination treatment (TCT) based on anti-PD-(L)1 and anti-4-1BB/OX40 and describes immunological mechanisms underlying synergism between the treatment components
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| |
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| Overall design |
Using bulk RNA seq of TILs isolated from isotype- and TCT-treated mice sorted based on expression of PD-1 and KLRG1 into 4 distinct populations, we established a gene expression profile of key CD8+ T cell populations induced by the TCT treatment. Using scRNA-Seq of TILs isolated from isotype- and TCT-tretaed mice we defined a sunctional, phenotypic and developmental T cell heterogeneity within treated and non treated tumors.
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| |
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| Contributor(s) |
Yang W, Budimir N |
| Citation(s) |
34903555 |
| |
| Submission date |
Oct 08, 2021 |
| Last update date |
Dec 21, 2021 |
| Contact name |
Wenjing Yanf |
| E-mail(s) |
[email protected]
|
| Organization name |
Pfizer
|
| Department |
Oncology
|
| Street address |
10770 Science Center Drive
|
| City |
San Diego |
| State/province |
CA |
| ZIP/Postal code |
92121 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (27)
|
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| This SubSeries is part of SuperSeries: |
| GSE181152 |
Combinatorial Immunotherapy Induces Tumor Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties |
|
| Relations |
| BioProject |
PRJNA769684 |
| SRA |
SRP340544 |
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