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Series GSE1864 Query DataSets for GSE1864
Status Public on Oct 27, 2004
Title A genomic view of estrogen actions in human breast cancer cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Changes in the expression of 8400 genes were monitored by cDNA microarray analysis during the first 32 h of human breast cancer (BC) ZR-75.1 cell stimulation with a mitogenic dose of 17beta-estradiol, a timing which corresponds to completion of a full mitotic cycle in hormone-stimulated cells. Hierarchical clustering of 344 genes whose expression either increases or decreases significantly in response to estrogen reveals that the gene expression program activated by the hormone in these cells shows 8 main patterns of gene activation/inhibition. This newly identified estrogen-responsive transcriptome represents more than a simple cell cycle response, as only a few affected genes belong to the transcriptional program of the cell division cycle of eukaryotes, or showed a similar expression profile in other mitogen-stimulated human cells. Indeed, based on the functions assigned to the products of the genes they control, estrogen appears to affect several key features of BC cells, including their metabolic status, proliferation, survival, differentiation and resistance to stress and chemotherapy, as well as RNA and protein synthesis, maturation and turn-over rates.
Keywords: time-course
 
 
Contributor(s) Cicatiello L, Scafoglio C, Altucci L, Cancemi M, Natoli G, Facchiano A, Iazzetti G, Calogero R, Biglia N, De Bortoli M, Sfiligoi C, Sismondi P, Bresciani F, Weisz A
Citation(s) 15171711
Submission date Oct 22, 2004
Last update date Jul 24, 2013
Contact name Angelo Facchiano
E-mail(s) [email protected]
Phone +39 0824 299625
Fax +39 0824 299813
URL http://bioinformatica.isa.cnr.it
Organization name Institute of Food Science
Lab Bioinformatics
Street address via Roma 52A/C
City Avellino
ZIP/Postal code 83100
Country Italy
 
Platforms (1)
GPL970 Incyte Human UniGEM V 2.0 (GEM-5112)
Samples (25)
GSM32870 estrogen actions in human breast cancer cells - 1 hr
GSM32871 Estrogen actions in human breast cancer cells - 2 hrs
GSM32872 Estrogen actions in human breast cancer cells - 4 hrs
Relations
BioProject PRJNA90489

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