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| Status |
Public on Oct 31, 2009 |
| Title |
Differentially expressed mRNA transcripts in the placenta delivered by preterm versus term spontaneous labour |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We hypothesized that preterm spontaneous labor involves aberrant changes in mRNA expression in the placenta. To test this hypothesis, we interrogated the mRNA levels of >50,000 genes and transcript variants using gene expression microarray (Human Genome U133 Plus 2.0 Array, Affymetrix) on 5 placentas collected from preterm spontaneous delivery (<34 weeks of gestation) and another 5 placentas collected from term spontaneous delivery (38-39 weeks).
We have identified 229 and 162 genes that were up- or down-regulated, respectively, for more than 3-fold in the preterm placentas compared to the term placentas (Mann-Whitney Rank Sum Test, with multiple testing correction by the Benjamini-Hochberg method, adjusted p-value <= 0.05).
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| Overall design |
Placentas collected from (i) preterm spontaneous delivery (<34 weeks of gestation) and (ii) term spontaneous delivery (38-39 weeks of gestation) were subjected to RNA extraction and hybridization on Affymetrix microarrays. To identify gene expression patterns that are commonly involved in preterm spontaneous labour, we analyzed 5 placentas from each of these 2 groups and tested for any differentially expressed genes by Mann-Whitney Rank Sum Test.
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| Contributor(s) |
Chim SS, Lee WS, Chiu RW, Leung TY, Lau TK, Lo YM |
| Citation(s) |
22496790 |
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| Submission date |
Oct 29, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Stephen S Chim |
| E-mail(s) |
[email protected]
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| Phone |
852-26321324
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| Fax |
852-26360008
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| URL |
http://www.obg.cuhk.edu.hk
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| Organization name |
The Chinese University of Hong Kong
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| Department |
Obstetrics & Gynaecology
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| Street address |
Dept of Obstetrics & Gynaecology, The Chinese University of Hong Kong
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| City |
Shatin |
| ZIP/Postal code |
NT |
| Country |
Hong Kong |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (10)
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| GSM466504 |
Placenta, Preterm spontaneous delivery, Biological Replicate #1 |
| GSM466505 |
Placenta, Preterm spontaneous delivery, Biological Replicate #2 |
| GSM466506 |
Placenta, Preterm spontaneous delivery, Biological Replicate #3 |
| GSM466507 |
Placenta, Preterm spontaneous delivery, Biological Replicate #4 |
| GSM466508 |
Placenta, Preterm spontaneous delivery, Biological Replicate #5 |
| GSM466509 |
Placenta, Term spontaneous delivery, Biological Replicate #1 |
| GSM466510 |
Placenta, Term spontaneous delivery, Biological Replicate #2 |
| GSM466511 |
Placenta, Term spontaneous delivery, Biological Replicate #3 |
| GSM466512 |
Placenta, Term spontaneous delivery, Biological Replicate #4 |
| GSM466513 |
Placenta, Term spontaneous delivery, Biological Replicate #5 |
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| Relations |
| BioProject |
PRJNA121227 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE18809_RAW.tar |
77.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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