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| Status |
Public on Dec 05, 2021 |
| Title |
RNA sequencing of hippocampus of Prnp+/+ and PrnpZH3/ZH3 animals |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: Gain insight into the gene expression patterns altered in the PrnpZH3/ZH3 mice, that correleate with their neurobehavioural impaiments. Results: Around 700 genes showed alterations in their expression profile (323 upregulated and 390 downregulated in PrnpZH3/ZH3 compared to Prnp+/+).
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| Overall design |
Methods: Hippocampal mRNA profiles of 17-20-week-old wild-type (WT) or PRNP ZH3 knock out mice (PRNP(ZH3/ZH3)) mice were generated by deep sequencing, 8 replicates per group.
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| Contributor(s) |
Matamoros-Angles A, Hervera A, Soriano J, Marti E, Carulla P, Llorens F, Nuvolone M, Aguzzi A, Ferrer I, Gruart A, Delgado-Garcia JM, Del Rio JA |
| Citation(s) |
35027047 |
| |
| Submission date |
Nov 28, 2021 |
| Last update date |
Jan 31, 2022 |
| Contact name |
Arnau Hervera |
| E-mail(s) |
[email protected]
|
| Organization name |
IBEC
|
| Street address |
Baldiri Reixac 15-21
|
| City |
Barcelona |
| ZIP/Postal code |
08028 |
| Country |
Spain |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA784185 |
| SRA |
SRP348224 |
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