|
| Status |
Public on Jan 30, 2010 |
| Title |
Transcriptomic Comparison in the Retinas of Two Mouse Models of Diabetes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Mouse models of type I diabetes offer the potential to combine genetic approaches with other pharmacological or physiological manipulations to investigate the pathophysiology and treatment of diabetic retinopathy. Type I diabetes is induced in mice through chemical toxins or may arise spontaneously from genetic mutations. Both models are associated with retinal vascular and neuronal changes. Retinal transcriptomic responses in C57BL/6J mice treated with strepotozotocin and Ins2Akita were compared after 3 months of hyperglycemia. Specific gene expression changes suggest a neurovascular inflammatory response in diabetic retinopathy. Genes common to the two models may represent the response of the retina to hyperglycemia; while changes unique to each model may represent time-dependent disease progression differences in the various models. Further investigation of the commonalities and differences between mouse models of type I diabetes may define cause and effect events in early diabetic retinopathy disease progression.
|
| |
|
| Overall design |
To compare two mouse models of type I diabetes, ie, STZ-induced and Ins2Akita, a gene expression analysis was conducted examining whole retinas collected after 3 months of hyperglycemia.
|
| |
|
| Contributor(s) |
Freeman WM, Bixler GV, Brucklacher RM, Walsh E, Kimball SR, Jefferson LS, Bronson SK |
| Citation(s) |
20157355 |
| |
| Submission date |
Nov 20, 2009 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Penn State COM |
| Organization name |
Penn State College of Medicine
|
| Department |
Genome Sciences Facility
|
| Street address |
500 University Drive
|
| City |
Hershey |
| State/province |
PA |
| ZIP/Postal code |
17033 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
|
| Samples (31)
|
|
| Relations |
| BioProject |
PRJNA120735 |
Less...
More...