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Series GSE19809 Query DataSets for GSE19809
Status Public on Jan 01, 2011
Title Efect of neonatal nutrition on adipose tissue remodeling genes during early development and in adult mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary While the phenomenon linking the early nutritional environment to disease susceptibility exists in many mammalian species, the underlying mechanisms are unknown. We hypothesized that nutritional programming is a variable quantitative state of gene expression, fixed by the state of energy balance in the neonate, that waxes and wanes in the adult animal in response to changes in energy balance. We tested this hypothesis with an experiment, based upon global gene expression, to identify networks of genes in which expression patterns in inguinal fat of mice have been altered by the nutritional environment during early post-natal development. Gene expression patterns in inguinal fat was assessed at 5, 10, 21 days of age and as adults fed chow (56 days of age) followed by high fat diet for 8 weeks (112 days of age) for C57BL/6J mice reared by lactating dams fed either a control diet (CONT), lactating dams fed a diet in which food intake was restricted to cause under-nourishment (lactation under-nutrition; LUN); and, lactating dams fed a high fat diet in where the number of progeny was limited to four (lactation over-nutrition; LON) .
 
Overall design 15 samples with 3 technical replicates of each sample. Each of the 15 samples consisted of pooled total RNA from 12 male mice. Dietary control samples are included for each time period.
 
Contributor(s) Kozak LP, Koza RA, Newman SS, Chao P, Mendoza T
Citation(s) 22383960, 20574519, 24808178, 28400497
Submission date Jan 08, 2010
Last update date May 01, 2017
Contact name Robert A. Koza
E-mail(s) [email protected]
Phone 225-763-3191
Organization name Pennington Biomedical Research Center
Department Genomics Core Facility
Street address
City Baton Rouge
State/province LA
ZIP/Postal code 70808
Country USA
 
Platforms (1)
GPL2995 ABI Mouse Genome Survey Microarray
Samples (45)
GSM494743 Day 5 Mouse inguinal fat control 1
GSM494744 Day 5 Mouse inguinal fat control 2
GSM494745 Day 5 Mouse inguinal fat control 3
Relations
BioProject PRJNA122079

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE19809_RAW.txt.gz 4.8 Mb (ftp)(http) TXT
Processed data included within Sample table
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