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| Status |
Public on Jul 19, 2022 |
| Title |
A novel prognostic risk model for cervical cancer based on immune checkpoint HLA-G-driven differentially expressed genes [HeLa] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The aim of this study was to construct and validate a prognostic risk model to predict the overall survival (OS) of patients with cervical cancer, providing a reference for individualized clinical treatment that may lead to better clinical outcomes.
HLA-G-driven DEG signature consisting of the eight most important prognostic genes CD46, LGALS9, PGM1, SPRY4, CACNB3, PLIN2, MSMO1, and DAGLB was identified as a key predictor of cervical cancer.
To summarize, we developed and validated a novel prognostic risk model for cervical cancer based on HLA-G-driven DEGs, and the prognostic signature showed great ability in predicting the overall survival of patients with cervical cancer.
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| Overall design |
HLA-G-driven differentially expressed genes (DEGs) were obtained from two cervical carcinoma cell lines, namely, SiHa and HeLa, with stable overexpression of HLA-G by RNA sequencing (RNA-seq).
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| Contributor(s) |
Xu H |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Jul 13, 2022 |
| Last update date |
Jul 19, 2022 |
| Contact name |
Hui-Hui Xu |
| E-mail(s) |
[email protected]
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| Phone |
+86-13757609637
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| Organization name |
Taizhou Hospital
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| Street address |
150
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| City |
Linhai |
| State/province |
Zhejiang province |
| ZIP/Postal code |
317000 |
| Country |
China |
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| Platforms (1) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE208119 |
A novel prognostic risk model for cervical cancer based on immune checkpoint HLA-G-driven differentially expressed genes |
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| Relations |
| BioProject |
PRJNA858423 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE208117_Processed_data_files_HeLa-HLA-G_VS._HeLa_FPKM.csv.gz |
335.0 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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