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| Status |
Public on Sep 14, 2023 |
| Title |
Transcriptome profile of hepatocellular carcinoma from non-alcoholic fatty liver. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Non-alcoholic fatty liver disease (NAFLD) is a major global health problem with its high prevalence and risk of developing lethal complications, progressive liver fibrosis and hepatocellular carcinoma (HCC), the only rising cancer mortality in the U.S. Ever after curative surgical resection, HCC can recur at extremely high rate (70% within 5 years); therefore, prediction of recurrent HCC is expected to guide decision of neo/adjuvant therapies currently under active development. Herein, we derived an HCC-transcriptome-based signature to predict disseminative recurrence, which originates from disseminated HCC cells from surgically resected initial tumor, and validated it in an independent cohort.
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| Overall design |
HCC tumor tissues were obtained from 45 patients who underwent surgically curative resection and used for RNA isolation and genome-wide transcriptome profiling by RNA-Seq.
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| Contributor(s) |
Fujiwara N, Zhu S, Hoshida Y |
| Citation(s) |
37621719 |
| |
| Submission date |
Sep 29, 2022 |
| Last update date |
Sep 14, 2023 |
| Contact name |
Yujin Hoshida |
| Organization name |
University of Texas Southwestern Medical Center
|
| Street address |
5323 Harry Hines Blvd
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| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75390 |
| Country |
USA |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (45)
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| This SubSeries is part of SuperSeries: |
| GSE214435 |
Disseminative Recurrence Signature for hepatocellular carcinoma from non-alcoholic fatty liver disease |
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| Relations |
| BioProject |
PRJNA885397 |
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