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| Status |
Public on Feb 02, 2023 |
| Title |
Spatially Resolved Transcriptomics Deconvolutes Histological Prognostic Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
This bulk mRNA data was generated using the Nanostring ncounter platform using an io360 pancancer panel of 900 genes as part of a wider project which included spatial transcriptomic data generated using the Nanostring GeoMx platform. In this study we compared tissue surgical resected from patients with colorectal cancer and liver metastases.
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| Overall design |
We compered the matched primary and metastatic lesions. The lesions were further annotated using histological scores to determine immune infiltration and stromal content, we further used these annotations to interrogate the mRNA data generated from nCounter
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| Contributor(s) |
Wood C, Pennel K, Leslie H, Legrini A, Cameron AJ, Melissourgou-Syka L, Quinn JA, van Wyk HC, Hay J, Roseweir AK, Nixon C, Roxburgh CS, McMillan DC, Biankin AV, Sansom OJ, Horgan PG, Edwards J, Steele CW, Jamieson NB |
| Citation(s) |
37057593 |
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| Submission date |
Feb 01, 2023 |
| Last update date |
May 11, 2023 |
| Contact name |
Colin Wood |
| E-mail(s) |
[email protected]
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| Phone |
07967593925
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| Organization name |
University of Glasgow
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| Department |
Academic Unit of Surgery
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| Street address |
84 Castle Street
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| City |
Glasgow |
| State/province |
Scotland |
| ZIP/Postal code |
G4 0SF |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL27956 |
NanoString Human nCounter PanCancer IO 360 Panel |
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| Samples (17)
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| Relations |
| BioProject |
PRJNA930377 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE224235_RAW.tar |
170.0 Kb |
(http)(custom) |
TAR (of RCC) |
| Processed data included within Sample table |
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