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| Status |
Public on Sep 04, 2023 |
| Title |
Total skin transcriptome modification induced by IL-17A blockade |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We studied psoriasis skin transcriptome modification induced by systemic IL-17A blockade with microarray analyses of total skin as part of a randomized placebo-controlled clinical trial (ClinicalTrial.gov identifier: NCT03131570)
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| Overall design |
Whole tissue samples of (1) 33 psoriasis skin lesions before IL-17A blockade, (2) 28 psoriasis skin lesions after IL-17A blockade, and (3) 8 normal skin (including GSE78097 data) were obtained via skin biopsy and subjected to microarray analysis.
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| Contributor(s) |
Krueger JG, Kim J |
| Citation(s) |
37781383 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| UL1 TR001866 |
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success |
THE ROCKEFELLER UNIVERSITY |
Barry Coller |
| K23 AR080043 |
A clinical trial for psoriasis with novel single-cell genomic techniques to understand regulatory immunity behind long-term disease remission off drug induced by short-term IL-23 inhibition |
UNIVERSITY OF CALIFORNIA DAVIS |
Jaehwan Kim |
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| |
| Submission date |
Feb 27, 2023 |
| Last update date |
Oct 03, 2023 |
| Contact name |
JAEHWAN KIM |
| Organization name |
University of California, Davis
|
| Department |
Dermatology
|
| Street address |
10535 Hospital Way
|
| City |
Sacramento |
| State/province |
CA |
| ZIP/Postal code |
95864 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (69)
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| Relations |
| BioProject |
PRJNA939227 |
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