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| Status |
Public on Apr 15, 2023 |
| Title |
Identifying the direct targets for transcription factor HIF-1a in Caenorhabditis elegans by ChIP-seq. |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Hypoxia-inducible transcription factor HIF is the key regulator of hypoxia response. It is conserved from human to the model organism C. elegans. The homolog of HIF in C. elegans is HIF-1. In C. elegans, there are six alternative splicing isoforms for HIF-1. Isoform a (HIF1a) is the predominant one with important biological functions for stress response and longevity. Here, by performing chromatin immunoprecipitation DNA-sequencing (ChIP-seq), we identified the direct targets for HIF-1a at whole genome level.
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| Overall design |
ChIP-seq with anti-HA
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| Contributor(s) |
Powell-Coffman JA, Feng D |
| Citation(s) |
38014054, 38743782 |
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| Submission date |
Apr 03, 2023 |
| Last update date |
May 16, 2024 |
| Contact name |
Jo Anne Powell-Coffman |
| E-mail(s) |
[email protected]
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| Phone |
515-294-3906
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| Organization name |
Iowa State University
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| Department |
Department of Genetics, Development and Cell Biology
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| Street address |
2213 Pammel Dr.
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| City |
Ames |
| State/province |
Iowa |
| ZIP/Postal code |
50011-1101 |
| Country |
USA |
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| Platforms (1) |
| GPL13657 |
Illumina HiSeq 2000 (Caenorhabditis elegans) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA951725 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE228846_RAW.tar |
925.0 Mb |
(http)(custom) |
TAR (of NARROWPEAK, WIG) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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