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| Status |
Public on Aug 21, 2023 |
| Title |
Effects of CDK8/19 Mediator Kinase inhibition by BI1347 and depletion by SNX7886 on gene expression in HEK293 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
RNA-Seq analysis was carried out to investigate the effects of selective CDK8/19 inhibitor BI1347 and PROTAC degrader SNX7886 on gene expression in HEK293 cells (293-WT) or the CDK8/19 double-knockout (293-dKO) derivatives.
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| Overall design |
293-WT or 293-dKO cells were treated with 0.1% DMSO (vehicle control) or 200nM BI1347 or 200nM SNX7886 for 3 days (72 hours). Each treatment condition was done in biological triplicate or quadruplicate.
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| Contributor(s) |
Chen M, Ji H, Roninson IB |
| Citation(s) |
37378433 |
| |
| Submission date |
May 08, 2023 |
| Last update date |
Aug 21, 2023 |
| Contact name |
HAO JI |
| E-mail(s) |
[email protected]
|
| Phone |
8037774689
|
| Organization name |
University of South Carolina
|
| Department |
College of Pharmacy
|
| Street address |
715 SUMTER ST CLS RM 109
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| City |
COLUMBIA |
| State/province |
SC |
| ZIP/Postal code |
29208 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (23)
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| Relations |
| BioProject |
PRJNA970192 |
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