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Series GSE23293 Query DataSets for GSE23293
Status Public on Mar 01, 2011
Title Definition and characterization of the systemic T cell dysregulation in untreated indolent B cell lymphoma and very early CLL
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Epidemiological data show that the immune system may control or promote emergence and growth of a neoplastic lymphomatous clone. Conversely, systemic lymphomas, especially myeloma and CLL, are associated with clinical immunodeficiency. This prospective controlled study demonstrates substantially reduced circulating T helper cells, predominantly naive CD4+ cells, in patients with non-leukemic follicular and extranodal marginal zone lymphomas, but not in monoclonal gammopathy and early CLL. These numerical changes were correlated with a preactivated phenotype, hyperreactivity in vitro, presenescence, and a Th2 shift of peripheral T helper cells. No prominent alterations were found in the regulatory T cell compartment. Gene expression profiling of in vitro-stimulated CD4+ cells revealed an independent second alteration of T helper cell physiology which was most pronounced in early CLL but also detectable in FL/eMZL. This pattern consisted of downregulation of proximal and intermediate T-cell receptor signaling cascades and globally reduced cytokine secretion. Both types of T cell dysfunction may contribute to significant immunodeficiency in non-leukemic indolent B-cell lymphomas as demonstrated by refractoriness to hepatitis B vaccination. The precise definition of systemic T cell dysfunction serves as the basis to study its prognostic impact, its relationship to the established influence of the lymphoma microenvironment, and its therapeutic manipulation
 
Overall design 8 samples from FL/eMZL patients, 7 samples from CLL patients, 5 samples of MGUS patients, 5 MALT, 16 healthy controls
 
Contributor(s) Christopoulos P, Pfeifer D, Bartholome K, Follo M, Timmer J, Fisch P, Veelken H
Citation(s) 21270444
Submission date Jul 28, 2010
Last update date Mar 25, 2019
Contact name Petros Christopoulos
Organization name Uniklinik Freiburg
Department Medizin I.
Street address Hugstetter Str. 55
City Freiburg
ZIP/Postal code 79106
Country Germany
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (41)
GSM571720 healthy CD4 cells - after stimulation - proband4
GSM571721 FL CD4 cells - after stimulation - proband5
GSM571722 CLL CD4 cells - after stimulation - proband7
Relations
BioProject PRJNA131357

Download family Format
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23293_RAW.tar 188.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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