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Series GSE24022 Query DataSets for GSE24022
Status Public on May 22, 2012
Title miRNA profiling of CD4+ T cells in chronically infected HIV-1 patients, LTNPs and healthy controls
Organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary We extracted total RNA from CD4+ T cells from 3 patient groups: chronic HIV-1 patients (CHI), long term non-progressors (LTNPs) and healthy controls (HC). Array results show that a large number of miRNAs are altered in HIV-1 infected patients compared to HC. Most of the differentially expressed miRNAs are down-regulated but there are some up-regulated miRNAs. A particular family of miRNAs which appear to be downregulated in HIV-1 infected patients is the let-7 family of miRNAs.
 
Overall design In this study, we have included 8 healthy controls, 7 LTNPs and 7 CHI patients. We extracted RNA from magnetically separated CD4+ T cells (separated from peripheral blood mononuclear cells) and ran them on an Agilent miRNA array.
 
Contributor(s) Swaminathan S, Suzuki K
Citation(s) 22586040
Submission date Sep 08, 2010
Last update date May 07, 2014
Contact name Sanjay Swaminathan
E-mail(s) [email protected]
Phone +61283824943
Fax +61283824967
Organization name St Vincent's Centre for Applied Medical Centre
Lab Immunovirology Laboratory
Street address 405 Liverpool St
City Darlinghurst
State/province New South Wales
ZIP/Postal code 2010
Country Australia
 
Platforms (1)
GPL8227 Agilent-019118 Human miRNA Microarray 2.0 G4470B (miRNA ID version)
Samples (22)
GSM591391 Ex-vivo CD4+ T cells RNA LTNP A
GSM591392 Ex-vivo CD4+ T cells RNA LTNP B
GSM591393 Ex-vivo CD4+ T cells RNA LTNP C
Relations
BioProject PRJNA130267

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE24022_RAW.tar 40.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
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