 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Oct 19, 2023 |
| Title |
Distinct Transcriptional Landscapes Identified by Radiographic Response in Metastatic Triple-Negative Breast Cancer Treated with Carboplatin, Nab-Paclitaxel, and Pembrolizumab in a Single-Arm Phase II Trial |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
A single arm, Phase II trial of carboplatin, nab-paclitaxel, and pembrolizumab (CNP) in metastatic triple negative breast cancer (mTNBC) was designed to evaluate overall response rate (ORR), progression-free survival (PFS), duration of response (DOR), safety/tolerability, and identify pathologic and transcriptomic correlates of response to therapy.
|
| |
|
| Overall design |
Single arm phase II clinical trial involving treatment of mTNBC patients with carboplatin, nab-paclitaxel, and pembrolizumab (CNP) to assess the overall response rate (ORR), overall and progression-free survival (OS, PFS), and toxicity profile associated with this particular combination of chemo-immunotherapeutic agents.
|
| |
|
| Contributor(s) |
Wilkerson AD, Parthasarathy PB, Stabellini N, Mitchell C, Pavicic PG Jr, Fu P, Makarov V, Rupani A, BA HH, Rayman PA, Swaidani S, Abraham J, Budd GT, Moore H, Al-Hilli Z, Ko JS, Baar J, Chan TA, Alban T, Diaz-Montero CM, Montero AJ |
| Citation(s) |
37882661 |
| |
| Submission date |
Aug 29, 2023 |
| Last update date |
Jan 16, 2024 |
| Contact name |
Vladimir Makarov |
| E-mail(s) |
[email protected]
|
| Phone |
2162879971
|
| Organization name |
CLEVELAND CLINIC LERNER COM-CWRU
|
| Street address |
9500 Euclid Ave
|
| City |
Cleveland |
| State/province |
OH |
| ZIP/Postal code |
44195 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (19)
|
|
| Relations |
| BioProject |
PRJNA1010464 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE241876_DeseqNormalizedCount.csv.gz |
4.3 Mb |
(ftp)(http) |
CSV |
| GSE241876_raw_count_matrix.csv.gz |
1.6 Mb |
(ftp)(http) |
CSV |
| GSE241876_readme.txt |
1.6 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...