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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Oct 16, 2010 |
| Title |
Specific functions for ERK/MAPK signaling during PNS development |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We have established functions of the stimulus dependent MAPKs, ERK1/2 and ERK5 in DRG, motor neuron, and Schwann cell development. Surprisingly, many aspects of early DRG and motor neuron development were found to be ERK1/2 independent and Erk5 deletion had no obvious effect on embryonic PNS. In contrast, Erk1/2 deletion in developing neural crest resulted in peripheral nerves that were devoid of Schwann cell progenitors, and deletion of Erk1/2 in Schwann cell precursors caused disrupted differentiation and marked hypomyelination of axons. The Schwann cell phenotypes are similar to those reported in neuregulin-1 and ErbB mutant mice and neuregulin effects could not be elicited in glial precursors lacking Erk1/2. ERK/MAPK regulation of myelination was specific to Schwann cells, as deletion in oligodendrocyte precursors did not impair myelin formation, but reduced precursor proliferation. Our data suggest a tight linkage between developmental functions of ERK/MAPK signaling and biological actions of specific RTK-activating factors.
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| Overall design |
Microarray analysis on RNA extracts derived from E12.5 Erk1/2CKO(Wnt1) and wildtype DRGs
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| Contributor(s) |
Newbern JM, Li X, Shoemaker SE, Zhou J, Zhong J, Wu Y, Bonder D, Hollenback S, Coppola G, Geschwind DH, Landreth GE, Snider WD |
| Citation(s) |
21220101 |
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| Submission date |
Oct 15, 2010 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Giovanni Coppola |
| E-mail(s) |
[email protected]
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| Phone |
310-794-4172
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| Organization name |
UCLA
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| Department |
Psychiatry and Neurology
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| Lab |
Neurogenetics
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| Street address |
1524 Gonda, 695 Charles Young Drive South
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| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90095 |
| Country |
USA |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA132351 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE24730_RAW.tar |
3.1 Mb |
(http)(custom) |
TAR |
| GSE24730_non-normalized.csv.gz |
925.3 Kb |
(ftp)(http) |
CSV |
| Processed data included within Sample table |
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