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| Status |
Public on Apr 13, 2012 |
| Title |
Prevention of acute liver failure |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Aim of this project was the evaluation of the effect of flushing (intraportal and intraoperative) hepatic allografts with tacrolimus before transplantation. Group A was administered tacrolimus, 20ng/ml in 1500ml albumin solution; and Group B was administered only albumin solution. Wedge biopsie of the allograft were harvested after 15 min flushing time and the gene expression profile were determined.
The primary study objective was to determine on a genome-wide basis whether intraoperative and intraportal treatment of the allograft with tacrolimus reduces inflammatory signature in the liver. The secondary objective was the causally test, whether suppression of genes belongong to the ontologies of inflammation and immune response by tacrolimus will lead to a better initial function of the liver.
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| Overall design |
randomized double-blind, placebo-controlled trial
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| Contributor(s) |
Wilflingseder J, Kristo I |
| Citation(s) |
21672049 |
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| Submission date |
Nov 15, 2010 |
| Last update date |
Jan 18, 2013 |
| Contact name |
Julia Wilflingseder |
| E-mail(s) |
[email protected]
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| Organization name |
Medical University of Vienna
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| Department |
Nephrology and Dialysis
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| Lab |
Laboratory Rainer Oberbauer
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| Street address |
Währinger Gürtel 18-20
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| City |
Vienna |
| ZIP/Postal code |
1090 |
| Country |
Austria |
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| Platforms (1) |
| GPL11209 |
[HuGene10stv1_Hs_ENSG] Affymetrix GeneChip Human Gene 1.0 ST Array [Brainarray Version 12] |
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| Samples (17)
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| GSM623464 |
group A, liver allograft wedge biopsie tacrolimus treatment 1 |
| GSM623465 |
group A, liver allograft wedge biopsie tacrolimus treatment 2 |
| GSM623466 |
group A, liver allograft wedge biopsie tacrolimus treatment 3 |
| GSM623467 |
group A, liver allograft wedge biopsie tacrolimus treatment 4 |
| GSM623468 |
group A, liver allograft wedge biopsie tacrolimus treatment 5 |
| GSM623469 |
group A, liver allograft wedge biopsie tacrolimus treatment 6 |
| GSM623470 |
group A, liver allograft wedge biopsie tacrolimus treatment 7 |
| GSM623471 |
group A, liver allograft wedge biopsie tacrolimus treatment 8 |
| GSM623472 |
group A, liver allograft wedge biopsie tacrolimus treatment 9 |
| GSM623473 |
group A, liver allograft wedge biopsie tacrolimus treatment 10 |
| GSM623474 |
group B, liver allograft wedge biopsie placebo treatment 1 |
| GSM623475 |
group B, liver allograft wedge biopsie placebo treatment 2 |
| GSM623476 |
group B, liver allograft wedge biopsie placebo treatment 3 |
| GSM623477 |
group B, liver allograft wedge biopsie placebo treatment 4 |
| GSM623478 |
group B, liver allograft wedge biopsie placebo treatment 5 |
| GSM623479 |
group B, liver allograft wedge biopsie placebo treatment 6 |
| GSM623480 |
group B, liver allograft wedge biopsie placebo treatment 7 |
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| Relations |
| BioProject |
PRJNA134869 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE25338_RAW.tar |
68.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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