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| Status |
Public on Jan 20, 2024 |
| Title |
The role of the C. albicans transcriptional repressor NRG1 during filamentation and disseminated candidiasis is strain-dependent |
| Organism |
Candida albicans |
| Experiment type |
Other
|
| Summary |
Clinical isolates of the human fungal pathogen Candida albicans show significant variation in their ability to undergo in vitro filamentation. In this study, we show that Nrg1, a key repressor of filamentation and filament specific gene expression in standard laboratory strain, has strain dependent functions, especially during infection.
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| Overall design |
In this experiment we characterize the expression profile of Candida albicans clinical isolates and their respective nrg1 mutant strains by NanoString. The probe set contains 186 environmentally responsive gene sets. 3 biological replicates (expection is 94015, in which only 2 biological replicates were used) were used to examine the expression of gene of interest.
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| Contributor(s) |
Wakade RS, Wellington M, Krysan DJ |
| Citation(s) |
38376205 |
| |
| Submission date |
Jan 19, 2024 |
| Last update date |
Apr 05, 2024 |
| Contact name |
Rohan S. Wakade |
| E-mail(s) |
[email protected]
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| Organization name |
University of Iowa
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| Department |
Department of Pediatrics
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| Street address |
25, South Grand Avenue, 2020 MedLabs, Department of Pediatrics
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| City |
Iowa City |
| State/province |
Iowa |
| ZIP/Postal code |
52242 |
| Country |
USA |
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| Platforms (1) |
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| Samples (44)
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| Relations |
| BioProject |
PRJNA1066834 |
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