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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jul 08, 2024 |
| Title |
Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
As a hallmark of cancer, altered metabolisms induce the suppression of anti-tumor immunity, contributing to immunotherapy resistance. Tumor metabolic reprogramming decreases immune effector cell infiltration, inhibits antigen priming and arrests expansion of effector cells. Therefore, we analyzed metabolism-related gene expression of tumors on a single-cell level using 3 tumor samples from breast cancer patients. We demonstrated that tumor cells with high metabolism-related expression evade immune surveillance.
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| Overall design |
scRNA-seq for breast tumors without neoadjuvant treatment
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| Contributor(s) |
Su S, Lu Y, Deng P, Li Y |
| Citation(s) |
38821061 |
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| Submission date |
Feb 05, 2024 |
| Last update date |
Jul 09, 2024 |
| Contact name |
Yihong Li |
| E-mail(s) |
[email protected]
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| Organization name |
Sun Yat-sen University
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| Street address |
Zhong shan Er lu
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| City |
Guangzhou |
| ZIP/Postal code |
510000 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA1073468 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE255068_Cell_anno.tsv.gz |
152.6 Kb |
(ftp)(http) |
TSV |
| GSE255068_RAW.tar |
292.5 Mb |
(http)(custom) |
TAR (of TAR) |
SRA Run Selector |
| Raw data are available in SRA |
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