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| Status |
Public on Dec 08, 2010 |
| Title |
Expression data from discodermolide sensitive and resistant cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Discodermolide treatment of A549 results in senescence. We compared cells resistant to disco-induced senescence to those that are sensitive to senescence induction. We also examined the gene expression of resistant (AD32) cells overexpressing 4E-BP1, a protein known to restore sensitivity to discodermolide in these cells.
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| Overall design |
Total RNA was collected from A549, A549 disco, AD32, and AD32 4E-BP1 cells and gene expression profiles were examined.
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| Contributor(s) |
Chao SK, Horwitz SB |
| Citation(s) |
21173253 |
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| Submission date |
Dec 07, 2010 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Susan K Chao |
| E-mail(s) |
[email protected]
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| Phone |
718-430-2361
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| Organization name |
Albert Einstein College of Medicine
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| Department |
Molecular Pharmacology
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| Lab |
Golding 201
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| Street address |
1300 Morris Park Ave
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| City |
Bronx |
| State/province |
NY |
| ZIP/Postal code |
10461 |
| Country |
USA |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (10)
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| GSM635873 |
resistant cells, biological replicate 1 |
| GSM635874 |
resistant cells, biological replicate 2 |
| GSM635875 |
resistant cells, biological replicate 3 |
| GSM635876 |
sensitive cells, biological replicate 1 |
| GSM635877 |
sensitive cells, biological replicate 2 |
| GSM635878 |
sensitive cells, biological replicate 3 |
| GSM635879 |
sensitive cells, biological replicate 4 |
| GSM635880 |
senescent cells, biological replicate 1 |
| GSM635881 |
senescent cells, biological replicate 2 |
| GSM635882 |
sensitive cells |
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| Relations |
| BioProject |
PRJNA135773 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE25904_RAW.tar |
41.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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