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| Status |
Public on Feb 13, 2011 |
| Title |
Hedgehog/GLI signalling and hormone independence in prostate cancer (PCa) cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
High levels of GLI (GLI1 and GLI2) mRNA and GLI luciferase reporter activity were detected in the androgen independent prostate cancer cell lines DU145 and PC-3 compared to the androgen-dependent LNCaP prostate cancer cell line. Subsequently, we observed that ectopic GLI1 promoted hormone independence in LNCaP cells (LNCaP-GLI1). We compared the gene expression profile of LNCaP-pBP (empty vector), LNCaP-GLI1, DU145, and PC-3 cells globally as well as to identify GLI1-regulated genes that may contribute to hormone independence.
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| Overall design |
RNA was harvested and analysed from LNCap-pBP (control/reference sample), LNCaP-GLI1, DU145 and PC-3 cells
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| Contributor(s) |
Nadendla SK, Neill GW |
| Citation(s) |
21633508 |
| |
| Submission date |
Feb 10, 2011 |
| Last update date |
Aug 16, 2018 |
| Contact name |
sandeep k Nadendla |
| E-mail(s) |
[email protected]
|
| Organization name |
qmul
|
| Department |
ccr
|
| Street address |
2 newark street
|
| City |
london |
| ZIP/Postal code |
e1 2at |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA137497 |
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