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Status |
Public on Dec 29, 2011 |
Title |
In vitro knockdown of LAMP3 leads to down-regulation of interferon-inducible genes |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
We identified LAMP3 as a key driver gene of anti-viral subnetwork genes in cervical cancer patients. Therefore we tested this prediction using an in vitro system. This is the first direct demonstration of LAMP3 regulatory role in interferon-dependent immune response.
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Overall design |
We first pretreated HeLa cells with control siRNA or LAMP3 siRNA overnight and then added 1 ng/ml of interferon alpha to the cultures for 3 and 4 days
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Contributor(s) |
Shulzhenko N, Morgun A |
Citation(s) |
23651994 |
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Submission date |
May 02, 2011 |
Last update date |
Aug 13, 2018 |
Contact name |
Natalia Shulzhenko |
E-mail(s) |
[email protected], [email protected]
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Organization name |
NIAID, USA
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Department |
Laboratory of Cellular and Molecular Immunology
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Lab |
Ghost lab
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Street address |
9000 Rockville Pike
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City |
Bethesda |
State/province |
MD |
ZIP/Postal code |
20892 |
Country |
USA |
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Platforms (1) |
GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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Samples (8)
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Relations |
BioProject |
PRJNA140461 |