|
| Status |
Public on Jul 09, 2012 |
| Title |
Comparison of the transcriptome of day 3 human embryo with that of the trophectoderm |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Third-party reanalysis
|
| Summary |
In humans, the embryonic genome activation (EGA) program is functional by day 3 after fertilization. The 6-8 cell stage embryo (day 3 post-fertilization) starts the process of “compaction” that leads to the generation of the tightly organized cell mass of the morula and is followed by differentiation of the morula into a blastocyst. The transition from day 3 embryos to day 5 blastocysts is likely to be controlled by many and specific changes in the expression of different genes. We used mRNA amplification technique and compared the transcriptomes of day 3 human embryos and trophectoderm (TE) cells from day 5 human blastocysts to identify transcripts that are differentially expressed during the embryo-to-TE transition and involved in the TE specification.
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| |
|
| Overall design |
These six embryo samples were compared to our five human trophectoderm samples that are available in GEO under the following accession numbers:
GSM706168
GSM706169
GSM706170
GSM706171
GSM706172
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| |
|
| Contributor(s) |
ASSOU S, DE VOS J, HAMAMAH S |
| Citation(s) |
22761758 |
| |
| Submission date |
Oct 17, 2011 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Said Assou |
| E-mail(s) |
[email protected]
|
| Organization name |
INSERM
|
| Street address |
80, Av. Augustin Flich
|
| City |
Montpellier |
| ZIP/Postal code |
34000 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (6)
|
|
| Relations |
| Reanalysis of |
GSM706168 |
| Reanalysis of |
GSM706169 |
| Reanalysis of |
GSM706170 |
| Reanalysis of |
GSM706171 |
| Reanalysis of |
GSM706172 |
| BioProject |
PRJNA148011 |
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