|
| Status |
Public on Jan 02, 2012 |
| Title |
Roles for ATF6-regulated miRNAs in the ER stress response |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
We wished to determine the effects of activating the transcription factor, ATF6, on global miRNA expression. We utilized transgenic mice with a conditionally tamoxien-responsive form of ATF6 and assessed cardiac lysates from NTG and TG mice, both treated with tamoxifen and untreated, in order to identify differentially expressed miRNAs. We then focused on miRNAs of interest as well as the genes they are predicted to regulate.
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| |
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| Overall design |
Four sample groups were assessed for miRNA expression: non-transgenic (NTG) mice treated with vehicle, NTG mice treated with tamoxifen, ATF6 transgenic (TG) mice treated with vehicle, and TG mice treated with tamoxifen
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| |
|
| Contributor(s) |
Belmont P, Glembotski C |
| Citation(s) |
22326432 |
| |
| Submission date |
Nov 07, 2011 |
| Last update date |
Aug 16, 2019 |
| Contact name |
Peter J Belmont |
| Organization name |
Pfizer
|
| Street address |
10724 Science Center Drive
|
| City |
San Diego |
| State/province |
CA |
| ZIP/Postal code |
92121 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL8530 |
LC_MRA-1002_miRMouse_13.0_090309 |
|
| Samples (6)
|
| GSM829366 |
Non-transgenic (NTG) mouse treated with vehicle (veh) replicate 1 |
| GSM829367 |
Non-transgenic (NTG) mouse treated with vehicle (veh) replicate 2 |
| GSM829368 |
Non-transgenic (NTG) mouse treated with vehicle (veh) replicate 3 |
| GSM829369 |
Transgenic (TG) mouse treated with vehicle (veh) replicate 1 |
| GSM829370 |
Transgenic (TG) mouse treated with vehicle (veh) replicate 2 |
| GSM829371 |
Transgenic (TG) mouse treated with vehicle (veh) replicate 3 |
|
| Relations |
| BioProject |
PRJNA148817 |
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