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| Status |
Public on May 25, 2014 |
| Title |
Genome-wide analysis of gene expression changes in mouse keratinocytes induced by treatment with DAPT |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of gene expression changes that occur in keratinocytes during reprogramming when they are treated with DAPT, a small molecule gamma-secretase inhibitor. The hypothesis tested in the present study was that Notch inhibition by DAPT treatment would promote reprogramming by inhibiting p21 activity while leaving p53 expression intact. Results provide important information of the gene expression changes in response to DAPT treatment, such as changes in the expression of p21, p21-responsive genes, p53, p53-responsive genes involved in apoptosis, and Notch-responsive genes.
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| |
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| Overall design |
Total RNA obtained from mouse keratinocytes transduced with reprogramming transcription factors and treated or not treated with DAPT for 4 days or 7 days.
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| |
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| Contributor(s) |
Ichida J |
| Citation(s) |
24952596 |
| |
| Submission date |
Jan 13, 2012 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Justin Ichida |
| E-mail(s) |
[email protected]
|
| Phone |
6172717366
|
| Organization name |
University of Southern California
|
| Street address |
1425 San Pablo St. Bcc 307
|
| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90033 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA150909 |
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