|
| Status |
Public on May 03, 2012 |
| Title |
Genotoxic alterations of cord blood cells in newborns exposed in utero to a zidovudine-based antiretroviral combination |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Background: Zidovudine remains the cornerstone drug for prophylaxis to prevent mother-to-child HIV-1 transmission. A mild but long-lasting hematological multilineage defect is observed in children exposed in utero.
Objectives: To evaluate the effects of zidovudine-based ARV combinations on newborn cord blood cells.
Methods: Cord blood-derived mononuclear cells from 22 HIV-1-uninfected newborn exposed in utero to a zidovudine-based ARV combination and from 20 healthy unexposed newborn were investigated by immunophenotyping, gene expression analysis, cytogenetic studies and functional capacity testing.
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| |
|
| Overall design |
To evaluate the effects of zidovudine-based ARV combinations on newborn cord blood cells.
|
| |
|
| Contributor(s) |
Andre-Schmutz I, Blanche S |
| Citation(s) |
23559464 |
| |
| Submission date |
May 03, 2012 |
| Last update date |
Jun 05, 2013 |
| Contact name |
Fabienne Cocchiarella |
| E-mail(s) |
[email protected]
|
| Phone |
+39 0592058062
|
| Fax |
+39 0592058116
|
| Organization name |
università di Modena e Reggio Emilia
|
| Department |
Scienze Biomediche
|
| Street address |
Via G. Gottardi
|
| City |
Modena |
| ZIP/Postal code |
41125 |
| Country |
Italy |
| |
|
| Platforms (1) |
| GPL14837 |
Affymetrix Human Genome U133 Plus 2.0 Array [CDF: XLab gahgu133plus2_2.1.0] |
|
| Samples (13)
|
| GSM926902 |
cord blood CD34+ from ARV-exposed newborns_A1 |
| GSM926903 |
cord blood CD34+ from ARV-exposed newborns_A5 |
| GSM926904 |
cord blood CD34+ from ARV-exposed newborns_A9 |
| GSM926905 |
cord blood CD34+ from ARV-exposed newborns_A14 |
| GSM926906 |
cord blood CD34+ from ARV-exposed newborns_A20 |
| GSM926907 |
cord blood CD34+ from ARV-exposed newborns_A21 |
| GSM926908 |
cord blood CD34+ from ARV-exposed newborns_A23 |
| GSM926909 |
cord blood CD34+ from control donors_T4 |
| GSM926910 |
cord blood CD34+ from control donors_T6 |
| GSM926911 |
cord blood CD34+ from control donors_T8 |
| GSM926912 |
cord blood CD34+ from control donors_T12 |
| GSM926913 |
cord blood CD34+ from control donors_T13 |
| GSM926914 |
cord blood CD34+ from control donors_T18 |
|
| Relations |
| BioProject |
PRJNA163075 |
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