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| Status |
Public on May 21, 2014 |
| Title |
Decrease of Parkin and CD36 expression and body weight correlate with an increase of non-esterified fatty acids in a mouse model for TDP-43 pathology |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
TDP-43-coding mutations are found among ALS patients. In oder to express human mutant TDP-43 protein in the mouse under the control of the endogenous Tardp promoter, we have generate a mouse line wit 300% elevated TDP-43 level.
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| |
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| Overall design |
Total RNA obtained from 4-6 male mutant mice was compared to 4-6 wild type controls.
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| |
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| Contributor(s) |
Beckers J, Floss T, Horsch M |
| Citation(s) |
24515116 |
| |
| Submission date |
Jul 23, 2012 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Martin Irmler |
| Organization name |
Helmholtz Zentrum München GmbH
|
| Department |
Institute of Experimental Genetics
|
| Lab |
Gene Regulation & Epigenetics
|
| Street address |
Ingolstaedter Landstrasse 1
|
| City |
Neuherberg |
| State/province |
Bayern |
| ZIP/Postal code |
85764 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
|
| Samples (20)
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| Relations |
| BioProject |
PRJNA171162 |
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