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Series GSE4005 Query DataSets for GSE4005
Status Public on Jan 11, 2006
Title Aging time course
Organism Caenorhabditis elegans
Experiment type Expression profiling by array
Summary Transcriptional Profile of Aging in C. elegans Whole-genome analysis of gene expression during chronological aging of the worm provides a rich database of age-specific changes in gene expression and represents one way to distinguish among these models. Using a rigorous statistical model with multiple replicates, we find that a relatively small number of genes (only 164) show statistically significant changes in transcript levels as aging occurs (<1% of the genome). Expression of heat shock proteins decreases, while expression of certain transposases increases in older worms, and these findings are consistent with a higher mortality risk due to a failure in homeostenosis and destabilization of the genome in older animals. Finally, a specific subset of genes is coordinately altered both during chronological aging and in the transition from the reproductive form to the dauer, demonstrating a mechanistic overlap in aging between these two processes.
Groups of assays that are related as part of a time series.
Age: Age of organism
Keywords: time_series_design
 
Overall design Computed
Web link http://cmgm.stanford.edu/~kimlab/aging/
 
Contributor(s) Lund J, Tedesco P
Citation(s) 12372248
Submission date Jan 10, 2006
Last update date Mar 16, 2012
Organization Stanford Microarray Database (SMD)
E-mail(s) [email protected]
Phone 650-498-6012
URL http://genome-www5.stanford.edu/
Department Stanford University, School of Medicine
Street address 300 Pasteur Drive
City Stanford
State/province CA
ZIP/Postal code 94305
Country USA
 
Platforms (5)
GPL2653 CE_printG_H_I
GPL2655 CE_PrintJ
GPL3096 Print_122
Samples (26)
GSM91446 N2 ref. JL1 vs. fer-15 day 9 (8/12/00)
GSM91447 N2 ref. JL1 vs. spe-9;fer-15 day 3 (1E)
GSM91448 N2 ref. JL1 vs. spe-9;fer-15 day 16 (49E)
Relations
BioProject PRJNA95223

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Supplementary data files not provided
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