|
| Status |
Public on Sep 07, 2012 |
| Title |
Studies on the Mechanism of Telavancin Decreased Susceptibility in a Laboratory-Derived Mutant |
| Organism |
Staphylococcus aureus |
| Experiment type |
Expression profiling by array
|
| Summary |
Telavancin is a novel semi-synthetic lipoglycopeptide derivative of vancomycin with a dual mode of action. This study sought to understand knowledge of mechanisms of decreased susceptibility in laboratory-derived mutant. There were multiple significant changes in the transcriptome of TlvDSMED1952 indicating an altered overall physiology of the strain, likely decreased virulence, and changes in cell wall and membrane properties, probably due to multiple genetic changes in the strain.
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| Overall design |
MHB cultures (biological replicates: N=3) were then grown to exponential phase (OD600=0.4). Dye-swapping was performed between samples.
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| Contributor(s) |
Song Y |
| Citation(s) |
23551248 |
| |
| Submission date |
Sep 07, 2012 |
| Last update date |
Aug 23, 2019 |
| Contact name |
Arunachalam Muthaiyan, Brian Wilkinson |
| E-mail(s) |
[email protected], [email protected]
|
| Phone |
309-438-7244
|
| URL |
http://www.bio.ilstu.edu/Wilkinson/
|
| Organization name |
Illinois State University
|
| Department |
Biological Sciences
|
| Lab |
Microbiology
|
| Street address |
Julian Hall
|
| City |
Normal |
| State/province |
IL |
| ZIP/Postal code |
61790 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL10591 |
JCVI PFGRC Staphylococcus aureus 16K v9 array designed primarily based on strain COL |
|
| Samples (3) |
| GSM999268 |
telavancin resistant strain vs. parent strain-rep1 |
| GSM999269 |
telavancin resistant strain vs. parent strain-rep2 |
| GSM999270 |
telavancin resistant strain vs. parent strain-rep3 |
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| Relations |
| BioProject |
PRJNA174632 |
