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| Status |
Public on Sep 05, 2013 |
| Title |
Canonical Nlrp3 inflammasome activation links systemic age-related inflammation with functional decline |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
This experiment was performed to analyze the contribution of NLRP3 inflammasome activation to age-related changes in hippocampal RNA. The hypothesis was that decreased inflammasome activation would reduce hippocampal inflammation.
Results indicate that inflammasome knockout animals are protected from age-related changes in hippocampal gene expression
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| Overall design |
Gene expression profiles of young (1 month) and old (21-23 month) wild type, CIAS -/- and ASC -/- mouse hippocampal tissue were compared. Total mRNA was extracted using Trizol.
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| Contributor(s) |
Youm Y, Dixit VD, Grant R, Albarado D, Ravussin A, Pistell P, Newman S, Laque A, Munzberg H, Ingram DK, Salbaum JM |
| Citation(s) |
24093676 |
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| Submission date |
Dec 19, 2012 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Ryan Grant |
| E-mail(s) |
[email protected]
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| Phone |
225-763-2763
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| Fax |
225-763-0261
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| Organization name |
Pennington Biomedical Research Center
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| Lab |
Immunobiology
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| Street address |
6400 Perkins Rd
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| City |
Baton Rouge |
| State/province |
LA |
| ZIP/Postal code |
70808 |
| Country |
USA |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (32)
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| GSM1055342 |
Hippocampus, Wild type, young (1 month)-1 |
| GSM1055343 |
Hippocampus, Wild type, young (1 month)-2 |
| GSM1055344 |
Hippocampus, Wild type, young (1 month)-3 |
| GSM1055345 |
Hippocampus, Wild type, young (1 month)-4 |
| GSM1055346 |
Hippocampus, Wild type, old (23 month)-1 |
| GSM1055347 |
Hippocampus, Wild type, old (23 month)-2 |
| GSM1055348 |
Hippocampus, Wild type, old (23 month)-3 |
| GSM1055349 |
Hippocampus, Wild type, old (23 month)-4 |
| GSM1055350 |
Hippocampus, Wild type, old (23 month)-5 |
| GSM1055351 |
Hippocampus, Wild type, old (23 month)-6 |
| GSM1055352 |
Hippocampus, ASC -/-, young (1 month)-1 |
| GSM1055353 |
Hippocampus, ASC -/-, young (1 month)-2 |
| GSM1055354 |
Hippocampus, ASC -/-, young (1 month)-4 |
| GSM1055355 |
Hippocampus, ASC -/-, old (23 month)-1 |
| GSM1055356 |
Hippocampus, ASC -/-, old (23 month)-2 |
| GSM1055357 |
Hippocampus, ASC -/-, old (23 month)-3 |
| GSM1055358 |
Hippocampus, ASC -/-, old (23 month)-4 |
| GSM1055359 |
Hippocampus, ASC -/-, old (23 month)-5 |
| GSM1055360 |
Hippocampus, ASC -/-, old (23 month)-6 |
| GSM1055361 |
Hippocampus, CIAS -/-, young (1 month)-1 |
| GSM1055362 |
Hippocampus, CIAS -/-, young (1 month)-2 |
| GSM1055363 |
Hippocampus, CIAS -/-, young (1 month)-4 |
| GSM1055364 |
Hippocampus, CIAS -/-, old (23 month)-1 |
| GSM1055365 |
Hippocampus, CIAS -/-, old (23 month)-2 |
| GSM1055366 |
Hippocampus, CIAS -/-, old (23 month)-3 |
| GSM1055367 |
Hippocampus, CIAS -/-, old (23 month)-4 |
| GSM1055368 |
Hippocampus, CIAS -/-, old (23 month)-5 |
| GSM1055369 |
Hippocampus, CIAS -/-, old (23 month)-6 |
| GSM1055370 |
Hippocampus, CASP 11-/-, young (1 month)-1 |
| GSM1055371 |
Hippocampus, CASP 11-/-, young (1 month)-2 |
| GSM1055372 |
Hippocampus, CASP 11-/-, young (1 month)-3 |
| GSM1055373 |
Hippocampus, CASP 11-/-, young (1 month)-4 |
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| Relations |
| BioProject |
PRJNA184139 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE43034_RAW.tar |
3.1 Mb |
(http)(custom) |
TAR |
| GSE43034_non-normalized.txt.gz |
4.9 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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