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| Status |
Public on Apr 03, 2013 |
| Title |
Molecular and Genetic Crosstalks Between mTOR and ERRα are Key Determinants of Rapamycin-induced Non-Alcoholic Fatty Liver. |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
mTOR and ERRα are key regulators of common metabolic processes. However, the extent of functional overlap between these two factors has not been investigated. ChIP-sequencing analyses on mouse liver reveal mTOR recruitment to regulatory regions of genes on a genome-wide scale including enrichment at genes shared with ERRα that are involved in the TCA cycle and lipogenesis pathway. A total of 9469 and 23226 peaks were identified for mTOR and ERRα ChIP-seq datasets, respectively.
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| Overall design |
mTOR and ERRα mouse liver ChIP-seq datasets obtained from pooling 8 individual ChIPs from a chromatin pool of 26 livers.
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| Contributor(s) |
Chaveroux C, Eichner LJ, Dufour CR, Shatnawi A, Khoutorsky A, Bourque G, Sonenberg N, Giguère V |
| Citation(s) |
23562079, 38537884 |
| |
| Submission date |
Jan 18, 2013 |
| Last update date |
Apr 17, 2024 |
| Contact name |
Vincent Giguère |
| Organization name |
McGill University
|
| Department |
Biochemistry, Medicine and Oncology
|
| Street address |
1160 Pine Avenue West, room 710A
|
| City |
Montréal |
| State/province |
Québec |
| ZIP/Postal code |
H3A 1A3 |
| Country |
Canada |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA186874 |
| SRA |
SRP018042 |
