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| Status |
Public on Dec 10, 2013 |
| Title |
Time course gene expression profiling of five diffuse large B-cell lymphoma cell lines following JQ1 treatment |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To understand the molecular curcuits perturbed by BET bromodoman inhibtion we obtained gene expression profiling of five DLBCL cell lines, SU-DHL6, OCI-Ly1, OCI-Ly4, Toledo and HBL-1, which were treated with either 500nM JQ1 or DMSO for 0,2,6,12,24 and 48hr.
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| Overall design |
RNA samples from five DLBCL cell lines at baseline (time 0) or following treatment with 500nM of JQ1 or vehicle (DMSO) alone for 2, 6, 24 or 48 hours were profiled in triplicate on Affymetrix Human Gene 1.0 ST Array.
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| Contributor(s) |
Chapuy B, McKeown M, Bradner JE, Shipp MA |
| Citation(s) |
24332044 |
| |
| Submission date |
Mar 29, 2013 |
| Last update date |
Dec 19, 2013 |
| Contact name |
Björn Chapuy |
| E-mail(s) |
[email protected]
|
| Phone |
+1-617-632-3881
|
| Organization name |
Dana-Farber Cancer Institute
|
| Department |
Medical Onology
|
| Lab |
Shipp Lab
|
| Street address |
450 Brookline Ave.
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
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| Platforms (1) |
| GPL16522 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [HuGene10stv1_Hs_ENTREZG_15.1.0] |
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| Samples (180)
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| Relations |
| BioProject |
PRJNA195432 |
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