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Series GSE4705

Query DataSets for GSE4705

Status

Public on Jan 20, 2007

Title

genome-wide expression analysis of the highly metastatic lung cancer cell line NCI-H460-LNM35

Organism

Homo sapiens

Experiment type

Expression profiling by array

Summary

Widespread metastasis is the major cause of human lung cancer-related deaths, but there is much to be elucidated about underlying mechanism. Based on the genome-wide expression analysis of the highly metastatic lung cancer cell line NCI-H460-LNM35 (LNM35), we identified a cancer metastasis signature composed of 45 genes with previously uncharacterized features but well-known associations with human cancers including CXCL1, IER3, PTTG1, DAD1, METAP2, E-cadherin and galectin 3. In addition, the 45-gene metastasis signature gene set was significantly associated with a subset of primary tumors with poor prognosis not only in the lung but also the breast.
Keywords: cell-line morphologic comparison

Overall design

Two sets of membrane cDNA microarrays (GeneFilter Human Microarrays Release I and Release II; Invitrogen, Carlsbad, CA), containing a total of 11,168 spots corresponding to 8,644 independent genes, were used to analyze genome-wide expression analysis in duplicate between highly metastatic lung cancer cell line NCI-H460-LNM35 and low metastatic NCI-H460-N15.

Contributor(s)

Tomida S, Yanagisawa K, Koshikawa K, Yatabe Y, Mitsudomi T, Osada H, Takashi T

Citation(s)

17260014

Submission date

Apr 24, 2006

Last update date

Mar 16, 2012

Contact name

Takashi Takahashi

Organization name

Aichi Cancer Center