 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Nov 09, 2013 |
| Title |
Circadian adaptive signaling to critical ROS stress for cell survival |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Disruption of circadian clocks exacerbates various diseases, in part likely due to impaired stress resistance. It is unclear how nearly lethal stresses affect circadian clocks. We found that near-lethal doses of reactive oxygen species (ROS)-induced critical oxidative stress (cOS) at the branch point of life and death resets circadian clocks, synergistically evoking protective responses for cell survival. The cOS-triggered clock resetting and pro-survival responses are mediated by transcription factor, central clock-regulatory BMAL1 and heat shock stress-responsive (HSR) HSF1. Casein kinase II (CK2) –mediated phosphorylation regulates dimerization and function of BMAL1 and HSF1 to control the cOS-evoked responses. The core cOS-responsive transcriptome includes CK2-orchestrated crosstalk between the circadian, HSR, NFκB-mediated anti-apoptotic, and Nrf2-mediated anti-oxidant pathways. This novel circadian-adaptive signaling system likely plays fundamental protective roles in ROS-inducible disorders, various diseases, and death.
|
| |
|
| Overall design |
Gene expression was measured 4h, 20h and 32h after treatment with 5 mM H2O2 for 10 min.
|
| |
|
| Contributor(s) |
Tamaru T, Hattori M, Ninomiya Y, Kawamura G, Vares G, Honda K, Mishra DP, Wang B, Benjamin I, Sassone-Corsi P, Ozawa T, Takamatsu K |
| Citation(s) |
24312621 |
| |
| Submission date |
Jun 14, 2013 |
| Last update date |
Jan 19, 2018 |
| Contact name |
Guillaume Vares |
| E-mail(s) |
[email protected]
|
| Phone |
0158359117
|
| Organization name |
IRSN
|
| Lab |
LRTOX
|
| Street address |
BP17
|
| City |
Fontenay-aux-Roses |
| ZIP/Postal code |
92262 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL10333 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version) |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA208467 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE47955_RAW.tar |
42.9 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...