|
| Status |
Public on Jun 23, 2014 |
| Title |
Ablation of Cdh1 and Trp53 in the uterus reveals novel mechanisms controlling tumor microenvironment in endometrial cancer. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Because TP53 mutation and CDH1 inactivation are the most common abnormalities found in human type II endometrial carcinomas, the contribution of dysfunctional TRP53 and CDH1 in the tumor microenvironment to induce type II endometrial cancer was characterized using mouse as a model. The results of our analysis revealed that conditional deletion of Cdh1 and Trp53 in the uterus regulated most of the genes categorized by their involvement in inflammatory responses, immune cell trafficking, cellular movement, cell-to-cell signaling and interaction and cellular growth and proliferation.
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| |
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| Overall design |
A direct comparison of mouse uteri (n=3) from control, single ablation of Cdh1 or Trp53, and ablation of both Cdh1 and Trp53 at 2 months of age.
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| |
|
| Contributor(s) |
Stodden GR, Lindberg ME, King ML, MacLean II JA, Hayashi K |
| Citation(s) |
24998851 |
| |
| Submission date |
Jun 19, 2013 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Kanako Hayashi |
| E-mail(s) |
[email protected]
|
| Organization name |
Washington State University
|
| Department |
School of Molecular Biosciences
|
| Street address |
BLS345, 1770 NE Stadium Way
|
| City |
Pullman |
| State/province |
WA |
| ZIP/Postal code |
99164 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (12)
|
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| Relations |
| BioProject |
PRJNA208971 |
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