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| Status |
Public on Oct 07, 2013 |
| Title |
The Wnt/β-catenin-signaling pathway is modulated by androgen ablation therapy for advanced clinical prostate cancer and contributes to androgen independent cell growth |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Androgen ablation therapy (AAT) is standard treatment for locally-advanced/metastatic prostate cancer (PCa). Many patients develop castration-resistance (CRPCa) after ~2-3 years, with a poor prognosis. The molecular mechanisms underlying CRPCa progression are unclear. mRNA-Seq was performed on tumours from 7 patients with locally-advanced/metastatic PCa before and ~22 weeks after AAT initiation. Differentially regulated genes were identified in treatment pairs.
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| |
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| Overall design |
Tumour biopsies from 7 patients were taken before and after AAT treatment
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| |
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| Contributor(s) |
Sudbery I, Rajan P, Villasevil MM, Mui E, Fleming J, Davis M, Abdul Razak AR, Ahmad I, Edwards J, Sansom OJ, Sims D, Ponting CP, Heger A, McMenemin RM, Pedley ID, Leung HY |
| Citation(s) |
24054872 |
| |
| Submission date |
Jun 28, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Ian Sudbery |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Sheffield
|
| Department |
Molecular Biology and Biotechnology
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| Lab |
Sudbery Lab for Computational Genomics
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| Street address |
Firth Court, Western Bank
|
| City |
Sheffield |
| ZIP/Postal code |
S11 8HG |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (14)
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| Relations |
| BioProject |
PRJNA209978 |
| SRA |
SRP026387 |
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