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| Status |
Public on Aug 15, 2013 |
| Title |
HuMiChip analysis of Saliva microbiota |
| Platform organism |
human metagenome |
| Sample organism |
human oral metagenome |
| Experiment type |
Genome variation profiling by array
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| Summary |
Human saliva microbiota is phylogenetically divergent among host individuals yet their roles in health and disease are poorly appreciated. We employed a microbial functional gene microarray, HuMiChip 1.0, to reconstruct the global functional profiles of human saliva microbiota from ten healthy and ten caries-active adults. Saliva microbiota in the pilot population featured a vast diversity of functional genes. No significant distinction in gene number or diversity indices was observed between healthy and caries-active microbiota. However, co-presence network analysis of functional genes revealed that caries-active microbiota was more divergent in non-core genes than healthy microbiota, despite both groups exhibited a similar degree of conservation at their respective core genes. Furthermore, functional gene structure of saliva microbiota could potentially distinguish caries-active patients from healthy hosts. Microbial functions such as Diaminopimelate epimerase, Prephenate dehydrogenase, Pyruvate-formate lyase and N-acetylmuramoyl-L-alanine amidase were significantly linked to caries. Therefore, saliva microbiota carried disease-associated functional signatures, which could be potentially exploited for caries diagnosis.
The DMFT INDEX (Decayed, Missing, Filled [DMF] teeth index used in dental epidemiology) values are provided for each sample
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| Overall design |
We employed a microbial functional gene microarray, HuMiChip 1.0, to reconstruct the global functional profiles of human saliva microbiota from ten healthy and ten caries-active adults.
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| Citation(s) |
24533043 |
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| Submission date |
Aug 14, 2013 |
| Last update date |
Feb 03, 2020 |
| Contact name |
Qichao Tu |
| E-mail(s) |
[email protected]
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| Organization name |
University of Oklahoma
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| Street address |
101 David L Boren Blvd
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| City |
Norman |
| State/province |
OK |
| ZIP/Postal code |
73019 |
| Country |
USA |
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| Platforms (1) |
| GPL17575 |
NimbleGen human oral metagenome array [HuMiChip V1.0] |
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| Samples (20)
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| GSM1208444 |
Human saliva microbiota from healthy adult_H102 |
| GSM1208445 |
Human saliva microbiota from healthy adult_H106 |
| GSM1208446 |
Human saliva microbiota from healthy adult_H107 |
| GSM1208447 |
Human saliva microbiota from healthy adult_H111 |
| GSM1208448 |
Human saliva microbiota from healthy adult_H112 |
| GSM1208449 |
Human saliva microbiota from healthy adult_H116 |
| GSM1208450 |
Human saliva microbiota from healthy adult_H117 |
| GSM1208451 |
Human saliva microbiota from healthy adult_H118 |
| GSM1208452 |
Human saliva microbiota from healthy adult_H121 |
| GSM1208453 |
Human saliva microbiota from healthy adult_H122 |
| GSM1208454 |
Human saliva microbiota from caries-active adult_C204 |
| GSM1208455 |
Human saliva microbiota from caries-active adult_C206 |
| GSM1208456 |
Human saliva microbiota from caries-active adult_C207 |
| GSM1208457 |
Human saliva microbiota from caries-active adult_C211 |
| GSM1208458 |
Human saliva microbiota from caries-active adult_C212 |
| GSM1208459 |
Human saliva microbiota from caries-active adult_C217 |
| GSM1208460 |
Human saliva microbiota from caries-active adult_C219 |
| GSM1208461 |
Human saliva microbiota from caries-active adult_C220 |
| GSM1208462 |
Human saliva microbiota from caries-active adult_C221 |
| GSM1208463 |
Human saliva microbiota from caries-active adult_C222 |
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| Relations |
| BioProject |
PRJNA215226 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE49875_RAW.tar |
25.8 Mb |
(http)(custom) |
TAR (of EXP) |
| Processed data included within Sample table |
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