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| Status |
Public on Apr 16, 2015 |
| Title |
Expression data from larvae body wall expressing LaminC transgenes |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by array
|
| Summary |
Expression of mutant lamins in human muscle causes muscular dystrophy. We have generated a drosophila model that expresses mutant lamins, modeled after those that cause disease in humans.
We used affymetrix microarrays to determine the global changes in gene expression caused by mutant lamins.
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| Overall design |
Dissected 3rd instar larval body wall from transgenic Drosophila expressing either a full length wildtype Lamin C, an N-terminal Lamin C truncation of the first 42 amino acids or a single amino acid substitution in Lamin C at position 489 from a G residue to a V residue under control of the Gal4-UAS.
RNA was extracted from 3rd instar larval body wall expressing these mutant Lamin C transgenes and microarray analysis using Affymetrix microarrays.
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| Contributor(s) |
Dialynas G, Thiemann D, Shrestha OK, Wallrath LL |
| Citation(s) |
25996830 |
| |
| Submission date |
Aug 18, 2013 |
| Last update date |
May 04, 2018 |
| Contact name |
Thomas B Bair |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Iowa
|
| Street address |
335 EMRB
|
| City |
Iowa City |
| State/province |
IA |
| ZIP/Postal code |
52242 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1322 |
[Drosophila_2] Affymetrix Drosophila Genome 2.0 Array |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA215688 |
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